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Special report on environmental endocrine disruption: an effects assessment and analysis: prepared for the Risk Assessment Forum
U.S. Government
Paperback. Books LLC, Reference Series 2011-10-01.
ISBN 9781234231279
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Förlagets beskrivning
Original publisher: Washington, D.C. : The Forum, [1997]. OCLC Number: (OCoLC)38918741 Subject: Endocrine glands -- Diseases -- Environmental aspects. Excerpt: ... capable of regulating minor changes to the endocrine milieu is uncertain. Finally, the data are not available for mixtures of chemicals that may be able to affect endocrine function. At the same time, in the case of environmental estrogens as endocrine disruptors, it is known that competition for binding sites by antiestrogens in the environment may moderate estrogenic effects of some chemicals. Clearly, more research to fill data gaps and remove the uncertainties in these unknowns is needed. c. Conclusions With few exceptions ( e.g., DES ), a causal relationship between exposure to a specific environmental agent and an adverse effect on human health operating via an endocrine disruption mechanism has not been established. However, in view of the Agency's concern that certain persistent chemicals might be responsible for some of the recently-reported reproductive, developmental, and carcinogenic effects operating through an endocrine disruption mechanism, new epidemiologic and laboratory testing studies could be undertaken to better define the scope of the problem. Short-term screening studies could be developed and validated in an effort to elucidate mechanisms. Biomarkers ( indicators ) of exposure could be defined and their concentrations related to degree of actual exposure. Studies of absorption, distribution, metabolism and elimination are essential for improving risk assessments by allowing extrapolation between species and assessing other routes of exposure. The reader is advised to refer to the report of the April 1995 endocrine disruptor workshop recommending specific high-priority research ( Kavlock et al., 1996 ). 2. Ecological Effects a. Types of Studies A number of laboratory and field investigations have been reported that provide information from which the potential effects of certai
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Special report on environmental endocrine disruption: an effects assessment and analysis: prepared for the Risk Assessment Forum
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